Diagnostic Value of S100B Protein in Critical Conditions
https://doi.org/10.15360/1813-9779-2011-6-72
Abstract
The review deals with possibilities for the quantitative assessment of the degree of brain injury, by measuring the level of S100B protein in various biological fluids. Data are given on changes in the concentration of this protein in different categories of patients, including those who are critically ill. Key words: S100B protein, laboratory diagnosis of critical conditions, biomarkers, perinatal brain lesions.
References
1. Moore B. W.
2. Whitelaw A., Rosengren L., Blennow M.Brain specific proteins in posthaemorrhagic ventricular dilatation. Arch. Dis. Child Fetal Neonatal Ed. 2001; 84 (2): F90—F91.
3. Schafer B. W., Fritschy J. M., Murmann P. et al.Brain S100A5 is a novel calcium-zinc- and copper ion-binding protein of the EF-hand super-family. J. Biol. Chem. 2000; 275 (39): 30623—30630.
4. Rothoerl R. D., Brawanski A., Woertgen C.S-100B protein serum levels after controlled cortical impact injury in the rat. Acta Neurochir. (Wien) 2001; 142 (2): 199—203.
5. Грудень М. А., Сторожева З. И., Шерстнев В. В.Регуляторные антитела к нейротрофическим факторам: клинико-экспериментальное исследование. В кн.: Нейроиммунопатология. М.: Медицина; 1999.
6. Donato R.S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int. J. Biochem. Cell Biol. 2001; 33 (7): 637—668.
7. Griffin S. W. T., Sheng J. G., Royston M. C. et al.Glia-neuronal interactions in Alzheimer’s disease: the potential role of a «cytokine cycle» in disease. Brain Pathol. 1998; 8 (1): 65—72.
8. Allore R., O Hanlon D., Price R. et al.Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome. Science 1988; 239 (4845): 1311 — 1313.
9. Траилин А. В., Левада О. А.Белок S100В: нейробиология, значение при неврологической и психиатрической патологии. Междунар. неврол. журн. 2009; 1: 166—175.
10. Beer C., Blacker D., Bynevelt M. et al.Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke. J. Neuroinflammation 2010; 7: 71.
11. EltingJ. W., deJager A. E., Teelken A. W. et al.Comparison of serum S-100 protein levels following stroke and traumatic brain injury. J. Neurol. Sci. 2000; 181 (1—2): 104—110.
12. Gazzolo D., Vinesi P., Bartocci M. et al.Elevated S100 blood level as early indicators of intraventricular hemorrhage in preterm infants. Correlation with cerebral Doppler velocimetry. J. Neurol. Sci. 1999; 170 (1): 32—35.
13. ГолоснаяГ. С., ПетрухинА. С., МаркевичК. А., ТрифоповаО. Е.Изменение уровня белка S-100 у новорожденных с перинатальным ги-поксическим поражением ЦНС. Педиатрия 2004; 1: 10—14.
14. Michetti F., Massaro A., Russo G., Rigon G.The S-100 antigen in cere-brospinal fluid as a possible index of cell injury in the nervous system. J. Neurol. Sci. 1980; 44 (2—3): 259—263.
15. Berger R. P., Pierce M. C., Wisniewski S. R. et al.Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics 2002; 109 (2): E31.
16. Garnier Y., Frigiola A., Li Volti G.Increased maternal/fetal blood S100B levels following systemic endotoxin administration and periventricular white matter injury in preterm fetal sheep. Reprod. Sci. 2009; 16 (8): 758—766.
17. Blennow M., Savman K., lives P. et al.Brain-specific proteins in the cere-brospinal fluid of severely asphyxiated newborn infants. Acta Paediatr. 2001; 90 (10): 1171—1175.
18. Gazzolo D., Bruschettini M., Lituania M. et al.S100B proteins in urine are correlated with gestational age in healthy preterm and term new-borns. Clin. Chem. 2001; 47 (6): 1132—1133.
19. Reiber H.Dynamics of brain-derived proteins in cerebrospinal fluid. Clin. Chim. Acta 2001; 310 (2): 173—186.
20. de Kruijk J. R., Leffers J. R., Menheere P. P. et al.S100B and neuron-specific enolase in serum of mild traumatic brain injury patients. A comparison with healthy controls. Acta Neurol. Scand. 2001; 103 (3): 175—179.
21. Anderson R. E., Hansson L. O., Nilsson O. et al.High serum S100B levels from trauma patients without head injuries. Neurosurgery 2001; 48 (6): 1255—1258.
22. Westaby S., Johnsson P., Parry A.J. et al.Serum S100 protein: a potential marker for cerebral events during cardiopulmonary bypass. Ann. Thorac. Surg. 1996; 61 (1): 88—92.
23. Gazzolo D., Vinesi P., Marinoni E. et al.S100B protein concentrations in cord blood: correlations with gestational age in term and preterm deliveries. Clin. Chem. 2000; 46 (7): 998—1000.
24. Gazzolo D., di Iorio R., Marinoni E. et al.S100B Protein is increased in asphyxiated term infants developing intraventricular hemorrhage. Crit. Care Med. 2002; 30 (6): 1356—1360.
25. Nagdyman N., Komen W., Ko H. K. et al.Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediatr. Res. 2001; 49 (4): 502—506.
26. Gazzolo D., Marinoni E., di Iorio R. et al.Circulating S100B protein is increased in intrauterine growth retarded fetuses. Pediatr. Res. 2002; 51 (2): 215—219.
27. Gazzolo D., Bruschettini M., Lituania M. et al.Increased urinary S100B protein as an early indicator of intraventricular hemorrhage in preterm infants: correlation with the grade of hemorrhage. Clin. Chem. 2001; 47 (10): 1836—1838.
28. Gazzolo D., Masetti P., Vinesi P. et al.S100B blood levels correlate with rewarming time and cerebral Doppler in pediatric open heart surgery. J. Card. Surg. 2002; 17 (4): 279-284.
29. Gazzolo D., Masetti P., Meli M. et al.Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracor-poreal membrane oxygenation. Acta Paediatr. 2002; 91 (2): 218—221.
30. PawluskiJ. L., Galea L. A., Brain U. et al.Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors. Pediatrics 2009; 124 (4): e662—e670.
31. Gazzolo D., Visser G. H. A., Lituania M. et al.S100B protein cord blood levels and fetal behavioural states of development: a study in normal and small for dates fetuses. J. Matern. Fetal Neonatal Med. 2002; 11 (6): 378—384.
32. Tramontina F., Leite M. C., Gongalves D. et al.High glutamate decreases S-100B secretion by a mechanism dependent on the glutamate transporter. Neurochem. Res. 2006; 31 (6): 815—820.
33. Jonsson H., Johnsson P., Hoglund P. et al.Elimination of S100B and renal function after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 2000; 14 (6): 698—701.
34. Gazzolo D., Abella R., Marinoni E. et al.New markers of neonatal neurology. J. Matern. Fetal Neonatal Med. 2009; 22 (Suppl 3): 57—61.
35. Friel L. A., Romero R., Edwin S. et al.The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J. Perinat. Med. 2007; 35 (5): 385—393.
36. Sen J., Belli A.S100B in neuropathologic states: the CRP of the brain? J. Neurosci. Res. 2007; 85 (7): 1373—1380.
37. Anderson R. E., Hansson L. O., Liska J. et al.The effect of cardiotomy suction on the brain injury marker S100B after cardiopulmonary bypass. Ann. Thorac. Surg. 2000; 69 (3): 847—850.
38. Carrier M., Denault A., Lavoie J., Perrault L. P.Randomized controlled trial of pericardial blood processing with a cell-saving device on neurologic markers in elderly patients undergoing coronary artery bypass graft surgery. Ann. Thorac. Surg. 2006; 82 (1): 51—55.
39. Wojtczak-Soska K., Lelonek M.S-100B protein: An early prognostic marker after cardiac arrest. Cardiol. J. 2010; 17 (5): 532—536.
40. B<3ttiger B. W., Mobes S., Glatzer R. et al.Astroglial protein S-100 is an early and sensitive marker of hypoxic brain damage and outcome after cardiac arrest in humans. Circulation 2001; 103 (22): 2694—2698.
41. Rosen H., Sunnerhagen K. S., Herlitz J. et al.Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. Resuscitation 2001; 49 (2): 183—191.
42. Ralay Ranaivo H., Craft J. M., Hu W. et al.Glia as a therapeutic target: selective suppression of human amyloid-/^-induced upregulation of brain proinflammatory cytokine production attenuates neurodegenera-tion. J. Neurosci. 2006; 26 (2): 662—670.
43. Nguyen D. N., Spapen H., Su F. et al.Elevated serum levels of S-100beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock. Crit. Care Med. 2006; 34 (7): 1967—1974.
44. Spapen H., Nguyen D. N., TroubleynJ. et al.Drotrecogin alfa (activated) may attenuate severe sepsis-associated encephalopathy in clinical septic shock. Crit. Care 2010; 14 (2): R54.
45. Lipcsey M., Olovsson M., Larsson E. et al.The brain is a source of S100B increase during endotoxemia in the pig. Anesth. Analg. 2010; 110 (1): 174—180.
46. Piazza O., Cotena S., De Robertis E. et al.Sepsis associated encephalopa-thy studied by MRI and cerebral spinal fluid S100B measurement. Neurochem. Res. 2009; 34 (7): 1289—1292.
47. Siami S., Annane D., Sharshar T.The encephalopathy in sepsis. Crit. Care Clin. 2008; 24 (1): 67—82, viii.
48. Hamed S. A., Hamed E. A., Zakary M. M.Oxidative stress and S-100B protein in children with bacterial meningitis. BMC Neurol. 2009; 9: 51.
49. Hamed S. A., Hamed E. A., Abdella M. M.Septic encephalopathy: relationship to serum and cerebrospinal fluid levels of adhesion molecules, lipid peroxides and S-100B protein. Neuropediatrics 2009; 40 (2): 66—72.
50. Gazzolo D., Grutzfeld D., Michetti F. et al.Increased S100B in cerebrospinal fluid of infants with bacterial meningitis: relationship to brain damage and routine cerebrospinal fluid findings. Clin. Chem. 2004; 50 (5): 941—944.
51. Кармен Н. Б., Мороз В. В., Маевский Е. И.Механизмы вторичного повреждения нейронов при тяжелой черепно-мозговой травме (часть 1). Общая реаниматология 2011; VII (4): 56—59.
52. Ельский В. Н., Зяблицев С. В., Якубенко Е. Д. и соавт.Перекисное окисление липидов при черепно-мозговой травме (экспериментальное исследование). Общая реаниматология 2009; V (4): 24—30.
53. Ohtaki N., Kamitani W., Watanabe Y. et al.Down regulation of an astro-cyte-derived inflammatory protein, S-100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus. J. Virol. 2007; 81 (11): 5940—5948.
54. dos Santos A. Q., Nardin P., Funchal C. et al.Resveratrol increases glu-tamate uptake and glutamine synthetase activity in C6 glioma cells. Arch. Biochem. Biophys. 2006; 453 (2): 161 — 167.
Review
For citations:
Beloborodova N.V., Dmitriyeva I.B., Chernevskaya E.A. Diagnostic Value of S100B Protein in Critical Conditions . General Reanimatology. 2011;7(6):72. (In Russ.) https://doi.org/10.15360/1813-9779-2011-6-72
Views: 1342
Email this article 